Symptoms often develop gradually and are easy to overlook at first. Early symptoms of kidney disease may include: constant fatigue, weakness, and difficulty concentrating due to a buildup of wastes in the blood. Swelling in the feet, ankles, hands, or face occurs when kidneys aren't pulling off excess fluid. Changes in urination are common warning signs: more frequent urination, foamy urine, dark-colored urine, or blood in the urine. Other symptoms may include nausea, loss of appetite, muscle cramps, dry itchy skin, and shortness of breath. It is important to seek early medical evaluation to avoid serious kidney complications.